The RIO trial: rationale, design, and the role of community involvement in a randomised placebo-controlled trial of antiretroviral therapy plus dual long-acting HIV-specific broadly neutralising antibodies (bNAbs) in participants diagnosed with recent HIV infection-study protocol for a two-stage randomised phase II trial.
Ming Jie LeeSimon CollinsDaphne BabalisNicholas JohnsonEmanuela FalaschettiA Toby PrevostAmbreen AshrafMilaana JacobTom ColeLisa HurleyMatthew PaceAne OgbeMaryam KhanPanagiota ZacharopoulouHelen BrownEuan SutherlandHanna BoxJulie FoxSteven DeeksJill HorowitzMichel C NussenzweigMarina CaskeyJohn FraterSarah FidlerPublished in: Trials (2022)
gov and EudraCT and has approval from UK Ethics and MHRA.
Keyphrases
- antiretroviral therapy
- double blind
- clinical trial
- study protocol
- open label
- placebo controlled
- phase iii
- hiv infected
- phase ii
- hiv positive
- human immunodeficiency virus
- hiv aids
- hiv infected patients
- randomized controlled trial
- public health
- healthcare
- mental health
- big data
- cross sectional
- hepatitis c virus
- machine learning