ALSUntangled #62: vitamin C.

Richard BedlackPaul BarkhausGreg CarterJesse CrayleChristopher J McDermottGary PatteeMeraida PolakKristiana SalmonPaul Wicks

Published in: Amyotrophic lateral sclerosis & frontotemporal degeneration (2021)

Vitamin C is one of the most common supplements taken by people with ALS. As an antioxidant, it has a plausible mechanism for slowing disease progression and there are some flawed pre-clinical studies and case reports suggesting benefit. However, a small human trial showed no benefit. Given this negative trial, we do not currently advise vitamin C as an ALS treatment.

Keyphrases

phase iii
study protocol
phase ii
clinical trial
endothelial cells
amyotrophic lateral sclerosis
randomized controlled trial
pluripotent stem cells
smoking cessation