The landscape of BRAF transcript and protein variants in human cancer.

Andrea MarranciZhijie JiangMarianna VitielloElena GuzzolinoLaura ComelliSamanta SartiSimone LubranoCinzia FranchinIleabett Echevarría-VargasAndrea TuccoliAlberto MercatantiMonica EvangelistaPaolo SportolettiGiorgio CozzaEttore LuziEnrico CapobiancoJessie VillanuevaGiorgio ArrigoniGiovanni SignoreSilvia RocchiccioliLetizia PittoNicholas TsinoremasLaura Poliseno

Published in: Molecular cancer (2017)

By shedding light on the repertoire of BRAF mRNA and protein variants, and on the complex regulation of their expression, our work paves the way to a deeper understanding of a crucially important player in human cancer and to a more informed development of new therapeutic strategies.

Keyphrases

endothelial cells
papillary thyroid
binding protein
squamous cell
copy number
poor prognosis
pluripotent stem cells
protein protein
amino acid
squamous cell carcinoma
gene expression
metastatic colorectal cancer
rna seq
dna methylation
childhood cancer