A Mendelian randomisation, propensity score matching study to investigate causal association between serum homocysteine and intracranial aneurysm.

Zhuohua Wen Xin Feng Xin TongChao PengAnqi XuHaiyan FanYiming BiWenchao LiuZhenjun LiShenquan GuoFa JinRan LiYanchao LiuShixing SuXin ZhangXifeng LiXuying HeAihua Liu Chuan-Zhi Duan

Published in: Stroke and vascular neurology (2023)

Both large-scale genetic evidence and multicentre real-world data support a causal association between tHcy and risk of IA formation. Serum tHcy may serve as a biomarker to identify high-risk individuals who would particularly benefit from folate supplementation.

Keyphrases

coronary artery
clinical trial
electronic health record
study protocol
big data
randomized controlled trial
cross sectional
copy number
dna methylation
double blind