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Genome-wide association meta-analysis of circulating odd-numbered chain saturated fatty acids: Results from the CHARGE Consortium.

Marcia C de Oliveira OttoRozenn N LemaitreQi SunIrena B KingJason H Y WuAni ManichaikulStephen S RichMichael Y TsaiY D ChenMyriam FornageGuan WeihuaStella AslibekyanMarguerite R IrvinEdmond K KabagambeDonna K ArnettMajken K JensenBarbara McKnightBruce M PsatyLyn M SteffenCaren E SmithUlf RisérusLars LindFrank B HuEric B RimmDavid S SiscovickDariush Mozaffarian
Published in: PloS one (2018)
Our findings suggest that circulating levels of OCSFA may be predominantly influenced by non-genetic factors. SNPs associated with C17:0 level in the LCT gene may reflect genetic influence in dairy consumption or in metabolism of dairy foods. SNPs associated with C23:0 may reflect a role of genetic factors in the synthesis of sphingomyelin.
Keyphrases
  • genome wide
  • genome wide association
  • copy number
  • systematic review
  • dna methylation
  • fatty acid
  • randomized controlled trial
  • gene expression