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Adiponectin, Free Fatty Acids, and Cardiovascular Outcomes in Patients With Type 2 Diabetes and Acute Coronary Syndrome.

Ilse C SchrieksAnna NozzaBarbara E StähliJohn B BuseRobert R HenryKlas MalmbergBruce NealStephen J NichollsLars RydénLinda MellbinAnders SvenssonHans WedelArlette WeichertA Michael LincoffJean-Claude TardifDiederick E GrobbeeGregory G Schwartz
Published in: Diabetes care (2018)
In contrast to prior observational data for incident CHD, adiponectin is prospectively associated with MACEs and death in patients with type 2 diabetes and ACS, and an increase in adiponectin from baseline is directly related to death. These findings raise the possibility that adiponectin has different effects in patients with type 2 diabetes and ACS than in populations without prevalent cardiovascular disease. Consistent with prior data, FFAs are directly associated with adverse outcomes.
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