First-in-human study of the safety, tolerability, pharmacokinetics and pharmacodynamics of single and multiple oral doses of SAR247799, a selective G-protein-biased sphingosine-1 phosphate receptor-1 agonist for endothelial protection.
Luc BergougnanSara ArmaniGeorg GolorAgnes TardatOlivier VitseFabrice HurbinMichel ScemamaFranck PoitiersDavid RadzikChristophe GaudinLionel HovsepianAnthony J MuslinStephane KirkesseliPaul DeutschAshfaq A ParkarPublished in: British journal of clinical pharmacology (2020)
SAR247799 is suitable for exploring the biological role of endothelial S1P1 activation without causing receptor desensitization.