The Clock gene regulates kainic acid-induced seizures through inhibiting ferroptosis in mice.
Fei WangLianxia GuoZhengping WuTianpeng ZhangDong DongBaojian WuPublished in: The Journal of pharmacy and pharmacology (2022)
CLOCK protects against KA-induced seizures through increased expression of GPX4 and PPAR-γ and inhibition of ferroptosis.
Keyphrases
- cell death
- temporal lobe epilepsy
- poor prognosis
- high glucose
- diabetic rats
- signaling pathway
- high fat diet induced
- genome wide
- insulin resistance
- copy number
- binding protein
- drug induced
- endothelial cells
- genome wide identification
- fatty acid
- gene expression
- oxidative stress
- skeletal muscle
- metabolic syndrome
- wild type
- genome wide analysis