Human breast microbiome correlates with prognostic features and immunological signatures in breast cancer.
Alice TzengNaseer SangwanMargaret JiaChin-Chih LiuKaren S KeslarErinn Downs-KellyRobert L FairchildZahraa Al-HilliStephen R GrobmyerCharis EngPublished in: Genome medicine (2021)
This study, the largest to date comparing healthy versus cancer-associated breast microbiomes using fresh-frozen surgical specimens and immune correlates, provides insight into microbial profiles that correspond with prognostic clinicopathologic features in breast cancer. It additionally presents evidence for local microbial-immune interplay in breast cancer that merits further investigation and has preventative, diagnostic, and therapeutic potential.