1,25-Dihydroxyvitamin D3 modulates adipogenesis of human adipose-derived mesenchymal stem cells dose-dependently.
Amin SalehpourMehdi HedayatiFarzad ShidfarAsal Neshatbini TehraniAli Asghar FarshadSaeed MohammadiPublished in: Nutrition & metabolism (2021)
Our findings revealed that 1,25-dihydroxyvitamin D3 may provoke adipocyte development in critical periods of adipogenesis at concentration of 10-8 M, thereby leading to a greater risk of obesity in adulthood and an augmented risk of obesity-related diseases including diabetes, cardiovascular diseases, and some cancers.
Keyphrases
- insulin resistance
- high fat diet induced
- type diabetes
- cardiovascular disease
- adipose tissue
- metabolic syndrome
- weight loss
- glycemic control
- endothelial cells
- skeletal muscle
- weight gain
- depressive symptoms
- induced pluripotent stem cells
- single cell
- cardiovascular risk factors
- pluripotent stem cells
- drug induced
- fatty acid
- coronary artery disease
- body mass index