Evaluating the optimum number of biopsies to assess histological inflammation in ulcerative colitis: a retrospective cohort study.
Robert BattatNiels Vande CasteeleRish K PaiZhongya WangGuangyong ZouJohn W D McDonaldMarjolijn DuijvesteinJenny JeyarajahClaire E ParkerTanja Van ViegenSigrid A NelsonBrigid S BolandSiddharth SinghParambir S DulaiMark A ValasekBrian G FeaganVipul JairathWilliam J SandbornPublished in: Alimentary pharmacology & therapeutics (2020)
A minimum of two - conservatively, three - biopsies are required to reliably assess disease activity in a single colonic segment using the RHI. Further studies are needed of endoscopically active patients and sampling locations. These results have implications for biopsy strategies in clinical trials and practice.
Keyphrases
- disease activity
- ulcerative colitis
- clinical trial
- rheumatoid arthritis
- systemic lupus erythematosus
- end stage renal disease
- ultrasound guided
- rheumatoid arthritis patients
- ejection fraction
- newly diagnosed
- ankylosing spondylitis
- chronic kidney disease
- healthcare
- primary care
- prognostic factors
- juvenile idiopathic arthritis
- randomized controlled trial
- fine needle aspiration
- quality improvement