Evaluating the Role of Circulating MicroRNAs to Aid Therapeutic Decision Making for Neoadjuvant Chemotherapy in Breast Cancer: A Prospective, Multicenter Clinical Trial.
Matthew G DaveyMaire Caitlin CaseyAndrew McGuireRonan M WaldronMaxwell PagangaEmma HolianJohn NewellHelen M HeneghanAilbhe M McDermottMaccon M KeaneAoife J LoweryNicola MillerMichael J KerinPublished in: Annals of surgery (2022)
This study illustrates the potential value of circulatory miRNA measurement in predicting response to NAC. Further interrogation of these findings may see miRNAs personalize therapeutic decision-making for patients undergoing NAC for early breast cancer.
Keyphrases
- neoadjuvant chemotherapy
- decision making
- early breast cancer
- clinical trial
- patients undergoing
- transcription factor
- locally advanced
- lymph node
- sentinel lymph node
- double blind
- squamous cell carcinoma
- cross sectional
- open label
- randomized controlled trial
- rectal cancer
- study protocol
- radiation therapy
- climate change
- childhood cancer
- breast cancer risk