Flavonoids and Organic Acids Affect Phase II Metabolism based on the Regulation of UGT1A1 Expression and Function.

Lin ZhangXuerong ZhangCaiyan Wang

Published in: Current computer-aided drug design (2024)

Above all, liquiritigenin and caffeic acid maintained the metabolism balance by upregulating the expression of UGT1A1 via Nrf2 activation and inhibiting the enzyme activity in Caco-2 cells.

Keyphrases

phase ii
poor prognosis
clinical trial
induced apoptosis
open label
oxidative stress
signaling pathway
cell cycle arrest
binding protein
long non coding rna
randomized controlled trial
cell death
cell proliferation
phase iii
pi k akt