Methods for delivering the UK's multi-centre prison-based naloxone-on-release pilot randomised trial (N-ALIVE): Europe's largest prison-based randomised controlled trial.

Angela Mary MeadeSheila Macdonald BirdJohn StrangTracey PeppleLaura Lea NicholsMonica MascarenhasLouise ChooMahesh Kumar Bhikhubhai Parmar

Published in: Drug and alcohol review (2017)

Prevention RCTs are seldom conducted within prisons; we demonstrated the feasibility of conducting a multi-prison RCT to prevent fatality from opioid overdose in the outside community. We terminated the N-ALIVE trial due to the infeasibility of individualised randomisation to naloxone-on-release. Large RCTs are feasible within prisons.

Keyphrases

study protocol
randomized controlled trial
clinical trial
open label
healthcare
chronic pain
mental health
pain management
phase iii
cross sectional
phase ii