Characterizing CD8+ TEMRA Cells in CP/CPPS Patients: Insights from Targeted Single-Cell Transcriptomic and Functional Investigations.
Fei ZhangQintao GeJia-Lin MengJia ChenChaozhao LiangMeng ZhangPublished in: ImmunoTargets and therapy (2024)
This study elucidates the pivotal role of the CD8+ TEMRA cell subset in CP/CPPS, which is characterized by increased TNF signaling and proinflammatory factor expression, highlighting potential biomarkers and opening new avenues for therapeutic intervention.
Keyphrases
- single cell
- rna seq
- end stage renal disease
- induced apoptosis
- randomized controlled trial
- chronic kidney disease
- ejection fraction
- newly diagnosed
- poor prognosis
- rheumatoid arthritis
- prognostic factors
- peritoneal dialysis
- cell cycle arrest
- cell therapy
- mesenchymal stem cells
- signaling pathway
- cell proliferation
- binding protein
- endoplasmic reticulum stress
- patient reported outcomes
- long non coding rna