Metformin Therapy Effects on the Expression of Sodium-Glucose Cotransporter 2, Leptin, and SIRT6 Levels in Pericoronary Fat Excised from Pre-Diabetic Patients with Acute Myocardial Infarction.

Celestino SarduNunzia D'OnofrioMichele TorellaMichele PortogheseSimone MuredduFrancesco LoreniFranca FerraraccioIacopo PanareseMaria Consiglia TrottaGianluca GattaMarilena Galdiero Ferdinando Carlo Sasso Michele D'AmicoMarisa De FeoMaria Luisa BalestrieriGiuseppe PaolissoRaffaele Marfella

Published in: Biomedicines (2021)

metformin therapy might ameliorate cardiovascular outcomes by reducing inflammatory parameters, SGLT2, and leptin levels, and finally improving SIRT6 levels in AMI-PDM patients treated with CABG.

Keyphrases

acute myocardial infarction
oxidative stress
poor prognosis
type diabetes
percutaneous coronary intervention
ischemia reperfusion injury
left ventricular
stem cells
heart failure
coronary artery disease
fatty acid
long non coding rna