Impact of Adjunctive Diode Laser Application to Non-Surgical Periodontal Therapy on Clinical, Microbiological and Immunological Outcomes in Management of Chronic Periodontitis: A Systematic Review of Human Randomized Controlled Clinical Trials.
Magdalena Pawelczyk-MadalińskaStefano BenedicentiTudor SălăgeanIoana Roxana BordeaReem HannaPublished in: Journal of inflammation research (2021)
In light of the confined evidence-based data and critical evaluation of this systematic review, the efficacy of adjunctive diode laser treatment ranging between 808 and 980nm to SRP remains debatable. The observational quality of the present systematic review was emphasised after scrutinising the available data, and an attempt to propose a laser protocol for future RCTs consideration was a great challenge due to an absence of clear and standardised recommendations in delivering a reliable laser protocol which can be replicable by future investigators. RCTs with robust methodology are warranted.
Keyphrases
- systematic review
- clinical trial
- meta analyses
- high speed
- randomized controlled trial
- electronic health record
- endothelial cells
- current status
- big data
- open label
- phase iii
- double blind
- stem cells
- machine learning
- skeletal muscle
- phase ii
- bone marrow
- cross sectional
- placebo controlled
- mass spectrometry
- clinical practice
- high resolution
- quality improvement
- replacement therapy
- weight loss