Validation of population-level HIV-1 incidence estimation by cross-sectional incidence assays in the HPTN 071 (PopART) trial.

Ethan KlockEthan WilsonReinaldo E FernandezEstelle Piwowar-ManningAyana MooreBarry KosloffJustin BwalyaNomtha Bell-MandlaAnelet JamesHelen AylesPeter BockDeborah DonnellSarah FidlerRichard HayesSusan H Eshleman Oliver Laeyendeckernull null

Published in: Journal of the International AIDS Society (2021)

MAA-C and the LAg+VL MAA provided accurate point estimates of incidence in this cohort with high levels of viral suppression. The Rapid+VL significantly underestimated incidence, suggesting that the MDRI recommended by the manufacturer is too long or the assay is not accurately detecting enough recent infections.

Keyphrases

risk factors
cross sectional
high throughput
clinical trial
antiretroviral therapy
hiv positive
hepatitis c virus
sars cov
high resolution
hiv infected
randomized controlled trial
hiv testing
phase iii
south africa
mass spectrometry