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A First-in-Human Phase I Study of Milademetan, an MDM2 Inhibitor, in Patients With Advanced Liposarcoma, Solid Tumors, or Lymphomas.

Mrinal M GounderTodd M BauerGary K SchwartzAmy M WeisePatricia LoRussoPrasanna KumarBen TaoYing HongParul PatelYasong LuArnaud LesegretainVijaya G TirunagaruFeng XuRobert C DoebeleDavid S Hong
Published in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2023)
An intermittent dosing schedule of 3/14 days of milademetan mitigates dose-limiting hematologic abnormalities while maintaining efficacy. Notable single-agent activity with milademetan in dedifferentiated liposarcomas has prompted a randomized phase III trial (MANTRA).
Keyphrases
  • phase iii
  • open label
  • clinical trial
  • phase ii
  • double blind
  • endothelial cells
  • placebo controlled
  • study protocol
  • induced pluripotent stem cells
  • randomized controlled trial
  • radiation induced