Measurement of changes in cerebrospinal fluid pulsation after traumatic brain injury using echo-planar imaging-based functional MRI.
Jun-Hee KimJae-Geun ImSung-Hong ParkPublished in: NMR in biomedicine (2023)
Traumatic brain injury (TBI) is a major public health concern worldwide, with a high incidence and a significant impact on morbidity and mortality. The alteration of cerebrospinal fluid (CSF) dynamics after TBI is a well-known phenomenon; however, the underlying mechanisms and their implications for cognitive function are not fully understood. In this study, we propose a new approach to studying the alteration of CSF dynamics in TBI patients. Our approach involves using conventional echo-planar imaging-based functional MRI with no additional scan, allowing for simultaneous assessment of functional CSF dynamics and blood oxygen level-dependent-based functional brain activities. We utilized two previously suggested indices of (i) CSFpulse, and (ii) correlation between global brain activity and CSF inflow. Using CSFpulse, we demonstrated a significant decrease in CSF pulsation following TBI (p < 0.05), which was consistent with previous studies. Furthermore, we confirmed that the decrease in CSF pulsation was most prominent in the early months after TBI, which could be explained by ependymal ciliary loss, intracranial pressure increment, or aquaporin-4 dysregulation. We also observed a decreasing trend in the correlation between global brain activity and CSF inflow in TBI patients (p < 0.05). Our findings suggest that the decreased CSF pulsation after TBI could lead to the accumulation of toxic substances in the brain and an adverse effect on brain function. Further longitudinal studies with larger sample sizes, TBI biomarker data, and various demographic information are needed to investigate the association between cognitive decline and CSF dynamics after TBI. Overall, this study sheds light on the potential role of altered CSF dynamics in TBI-induced neurologic symptoms and may contribute to the development of novel therapeutic interventions.
Keyphrases
- traumatic brain injury
- cerebrospinal fluid
- severe traumatic brain injury
- mild traumatic brain injury
- end stage renal disease
- cognitive decline
- public health
- ejection fraction
- chronic kidney disease
- newly diagnosed
- magnetic resonance
- magnetic resonance imaging
- high resolution
- physical activity
- emergency department
- resting state
- prognostic factors
- peritoneal dialysis
- diffusion weighted imaging
- electronic health record
- patient reported outcomes
- blood brain barrier
- climate change
- depressive symptoms
- computed tomography
- cross sectional
- social media
- health information
- endothelial cells
- sleep quality