Diagnostic and prognostic impact of cytokeratin 18 expression in human tumors: a tissue microarray study on 11,952 tumors.

Anne MenzTimo WeitbrechtNatalia GorbokonFranziska BüscheckAndreas M LuebkeMartina KluthClaudia Hube-MaggAndrea HinschDoris HöflmayerSören WeidemannChristoph FrauneKatharina MöllerChristian BernreutherPatrick LebokTill ClauditzGuido SauterRia UhligWaldemar WilczakStefan SteurerSarah MinnerEike BurandtRainer KrechDavid DumTill KrechAndreas MarxRonald Simon

Published in: Molecular medicine (Cambridge, Mass.) (2021)

Down-regulation or loss of CK18 expression in cancers arising from CK18 positive tissues as well as CK18 neo-expression in cancers originating from CK18 negative tissues is linked to cancer progression and may reflect tumor dedifferentiation.

Keyphrases

poor prognosis
protein kinase
gene expression
endothelial cells
squamous cell carcinoma
papillary thyroid
young adults
squamous cell
induced pluripotent stem cells
childhood cancer
pluripotent stem cells