A brief overview of SARS-CoV-2 infection and its management strategies: a recent update.
Alakesh DasSurajit PathakMadhavi PremkumarChitra Veena SarpparajanEsther Raichel BalajiAsim K DuttaroyGanesan JothimaniPublished in: Molecular and cellular biochemistry (2023)
The COVID-19 pandemic has become a global health crisis, inflicting substantial morbidity and mortality worldwide. A diverse range of symptoms, including fever, cough, dyspnea, and fatigue, characterizes COVID-19. A cytokine surge can exacerbate the disease's severity. This phenomenon involves an increased immune response, marked by the excessive release of inflammatory cytokines like IL-6, IL-8, TNF-α, and IFNγ, leading to tissue damage and organ dysfunction. Efforts to reduce the cytokine surge and its associated complications have garnered significant attention. Standardized management protocols have incorporated treatment strategies, with corticosteroids, chloroquine, and intravenous immunoglobulin taking the forefront. The recent therapeutic intervention has also assisted in novel strategies like repurposing existing medications and the utilization of in vitro drug screening methods to choose effective molecules against viral infections. Beyond acute management, the significance of comprehensive post-COVID-19 management strategies, like remedial measures including nutritional guidance, multidisciplinary care, and follow-up, has become increasingly evident. As the understanding of COVID-19 pathogenesis deepens, it is becoming increasingly evident that a tailored approach to therapy is imperative. This review focuses on effective treatment measures aimed at mitigating COVID-19 severity and highlights the significance of comprehensive COVID-19 management strategies that show promise in the battle against COVID-19.
Keyphrases
- coronavirus disease
- sars cov
- immune response
- respiratory syndrome coronavirus
- public health
- global health
- randomized controlled trial
- healthcare
- rheumatoid arthritis
- oxidative stress
- stem cells
- dendritic cells
- quality improvement
- risk factors
- body mass index
- mesenchymal stem cells
- intensive care unit
- high dose
- machine learning
- liver failure
- toll like receptor
- cell therapy
- mechanical ventilation
- smoking cessation
- plasmodium falciparum
- replacement therapy
- chemotherapy induced