A Novel Transcription Factor Combination for Direct Reprogramming to a Spontaneously Contracting Human Cardiomyocyte-like State.

Marisol Romero-Tejeda Hananeh Fonoudi Carly J Weddle Jean-Marc DeKeyserBrian LennyK Ashley Fetterman Tarek Magdy Yadav Sapkota Conrad L Epting Maged M Costantine

Published in: bioRxiv : the preprint server for biology (2023)

(MST) as the most successful direct reprogramming combination. MST cocktail results in reprogrammed cells with spontaneous contraction, cardiomyocyte-like calcium transients, and expression of cardiomyocyte associated genes.

Keyphrases

angiotensin ii
transcription factor
endothelial cells
induced apoptosis
high glucose
poor prognosis
cell cycle arrest
genome wide
genome wide identification
induced pluripotent stem cells
pluripotent stem cells
oxidative stress
gene expression
dna methylation
cell death
long non coding rna
binding protein