Expression patterns of HNF4α, TTF-1, and SMARCA4 in lung adenocarcinomas: impacts on clinicopathological and genetic features.
Hitomi KawaiTamaki MiuraNatsumi KawamatsuTomoki NakagawaAya Shiba-IshiiTaichiro YoshimotoYusuke AmanoAtsushi KiharaYuji SakumaKazutaka FujitaTomoki ShibanoShumpei IshikawaTetsuo UshikuMasashi FukayamaHiroyoshi TsubochiShunsuke EndoKoichi HagiwaraDaisuke MatsubaraToshiro NikiPublished in: Virchows Archiv : an international journal of pathology (2024)
HNF4α-positive non-mucinous adenocarcinomas included TRU-type and non-TRU-type cases; the latter tended to exhibit the high-grade phenotype with frequent loss of SMARCA4, and A549 was a representative cell line.