Expression of SARS-CoV-2 entry factors in lung epithelial stem cells and its potential implications for COVID-19.
Anna A ValyaevaAnastasia A ZharikovaArtem S KasianovYegor S VassetzkyEugene V ShevalPublished in: Scientific reports (2020)
SARS-CoV-2 can infiltrate the lower respiratory tract, resulting in severe respiratory failure and a high death rate. Normally, the airway and alveolar epithelium can be rapidly reconstituted by multipotent stem cells after episodes of infection. Here, we analyzed published RNA-seq datasets and demonstrated that cells of four different lung epithelial stem cell types express SARS-CoV-2 entry factors, including Ace2. Thus, stem cells can be potentially infected by SARS-CoV-2, which may lead to defects in regeneration capacity partially accounting for the severity of SARS-CoV-2 infection and its consequences.
Keyphrases
- sars cov
- stem cells
- rna seq
- respiratory syndrome coronavirus
- respiratory tract
- single cell
- respiratory failure
- cell therapy
- induced apoptosis
- extracorporeal membrane oxygenation
- poor prognosis
- coronavirus disease
- oxidative stress
- randomized controlled trial
- cell proliferation
- cell cycle arrest
- systematic review
- early onset
- binding protein
- angiotensin converting enzyme