A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial to Investigate the Effects of Kamishoyosan, a Traditional Japanese Medicine, on Menopausal Symptoms: The KOSMOS Study.
Kiyoshi TakamatsuMariko OgawaSatoshi ObayashiTakashi TakedaMasakazu TerauchiTsuyoshi HiguchiKiyoko KatoToshiro KubotaPublished in: Evidence-based complementary and alternative medicine : eCAM (2021)
Although no significant difference was identified for the primary outcome, a significantly higher proportion of patients who received TJ-24 displayed improvement. Its high level of safety and effects on excitability and irritability in premenopausal women suggest that TJ-24 may be a useful treatment.
Keyphrases
- double blind
- placebo controlled
- clinical trial
- phase iii
- phase ii
- study protocol
- polycystic ovary syndrome
- postmenopausal women
- type diabetes
- breast cancer risk
- open label
- randomized controlled trial
- metabolic syndrome
- pregnant women
- cross sectional
- pregnancy outcomes
- physical activity
- adipose tissue
- early breast cancer