Radix Astragali-Based Chinese Herbal Medicine for Oxaliplatin-Induced Peripheral Neuropathy: A Systematic Review and Meta-Analysis.
Bo DengLiqun JiaZhiqiang ChengPublished in: Evidence-based complementary and alternative medicine : eCAM (2016)
Background. Treatment of chemotherapy-induced peripheral neuropathy (CIPN) remains a big challenge for oncologists. The aim of this study is to evaluate the effects of Radix Astragali- (RA-) based Chinese herbal medicine in the prevention and treatment of oxaliplatin-induced peripheral neuropathy, including the incidence and grading of neurotoxicity, effective percentage, and nerve conduction velocity. Methods. All randomized controlled trials (RCTs) were found using PubMed, Cochrane, Springer, China National Knowledge Infrastructure (CNKI), and Wanfang Database of China Science Periodical Database (CSPD) by keyword search. Meta-analysis was conducted using RevMan 5.0. Results. A total of 1552 participants were included in 24 trials. Meta-analysis showed the incidence of all-grade neurotoxicity was significantly lower in experimental groups and high-grade neurotoxicity was also significantly less. Effective percentage was significantly higher and sensory nerve conduction velocity was improved significantly, but changes in motor nerve conduction velocity were not statistically significant. No adverse events associated with RA-based intervention were reported. Conclusion. RA-based intervention may be beneficial in relieving oxaliplatin-induced peripheral neuropathy. However, more double-blind, multicenter, large-scale RCTs are needed to support this theory. Trial Registration. PROSPERO International prospective register of systematic reviews has registration number CRD42015019903.
Keyphrases
- systematic review
- randomized controlled trial
- meta analyses
- high glucose
- high grade
- rheumatoid arthritis
- diabetic rats
- chemotherapy induced
- study protocol
- double blind
- healthcare
- public health
- drug induced
- blood flow
- disease activity
- risk factors
- machine learning
- low grade
- adverse drug
- big data
- peripheral nerve
- ankylosing spondylitis
- artificial intelligence
- phase ii
- cross sectional
- stress induced
- idiopathic pulmonary fibrosis