Leptin is a potential biomarker of childhood obesity and an indicator of the effectiveness of weight-loss interventions.
Mohammad Al ZeinAishat Funmilayo AkomolafeFathima R MahmoodAli KhrayzatAmir Hossein SahebkarGianfranco PintusFiras KobeissyAli Hussein EidPublished in: Obesity reviews : an official journal of the International Association for the Study of Obesity (2024)
Childhood obesity represents a significant public health concern, imposing a substantial burden on the healthcare system. Furthermore, weight-loss programs often exhibit reduced effectiveness in adults who have a history of childhood obesity. Therefore, early intervention against childhood obesity is imperative. Presently, the primary method for diagnosing childhood obesity relies on body mass index (BMI), yet this approach has inherent limitations. Leptin, a satiety hormone produced by adipocytes, holds promise as a superior tool for predicting both childhood and subsequent adulthood obesity. In this review, we elucidate the tools employed for assessing obesity in children, delve into the biological functions of leptin, and examine the factors governing its expression. Additionally, we discuss maternal and infantile leptin levels as predictors of childhood obesity. By exploring the relationship between leptin levels and weight loss, we present leptin as a potential indicator of the effectiveness of obesity interventions.
Keyphrases
- weight loss
- bariatric surgery
- weight gain
- body mass index
- public health
- roux en y gastric bypass
- randomized controlled trial
- gastric bypass
- systematic review
- insulin resistance
- physical activity
- type diabetes
- glycemic control
- high fat diet induced
- adipose tissue
- poor prognosis
- young adults
- pregnant women
- long non coding rna
- artificial intelligence