Plasma Membrane Channel TRPM4 Mediates Immunogenic Therapy-Induced Necrosis.

Santanu Ghosh Rachel Yang Darjan Duraki Junyao Zhu Ji Eun Kim Musarrat Jabeen Chengjian Mao Xinyi Dai Mara R Livezey Matthew W Boudreau Ben Ho Park Erik Russell Nelson Paul J Hergenrother David J Shapiro

Published in: Cancer research (2023)

A genome-wide CRISPR screen reveals a pivotal role for TRPM4 in cell death and immune activation following treatment with diverse necrosis-inducing anticancer therapies, which could facilitate development of necrosis-based cancer immunotherapies.

Keyphrases

genome wide
cell death
dna methylation
papillary thyroid
crispr cas
high glucose
high throughput
genome editing
squamous cell
copy number
diabetic rats
gene expression
stem cells
drug induced
squamous cell carcinoma
endothelial cells
cell cycle arrest
cell therapy
lymph node metastasis