A Coupled FEM-SPH Modeling Technique to Investigate the Contractility of Biohybrid Thin Films.
Lorenzo VannozziTommaso MazzocchiArihiro HasebeShinji TakeokaToshinori FujieLeonardo RicottiPublished in: Advanced biosystems (2020)
Biohybrid actuators have the potential to overcome the limitations of traditional actuators employed in robotics, thanks to the unique features of living contractile muscle cells, which can be used to power artificial elements. This paper describes a computational approach for the estimation of the contractile capabilities of skeletal muscle cell-powered biohybrid actuators based on polymeric thin films. The proposed model grounds on the coupling between finite element modeling and smooth particle hydrodynamics. This allows describing the overall condition, including the viscous forces caused by the surrounding liquid medium, in which biohybrid systems are normally immersed. The model is calibrated by analyzing the contractile behavior of polydimethylsiloxane films coupled with skeletal muscle cells, reported in the literature as muscular thin films. Afterward, it is applied to poly (D, L-lactic acid) thin films to explore the behavior of these systems, due to myotubes cultured on them, evaluating the role of thickness, tissue maturation status, and hydrostatic pressure on the contractile performance. These results pave the way toward a novel optimization approach of biohybrid robot design relying on the simulation of all the boundary conditions, thus reducing the need for extensive trial-and-error efforts.
Keyphrases
- skeletal muscle
- induced apoptosis
- insulin resistance
- cell cycle arrest
- lactic acid
- smooth muscle
- finite element
- systematic review
- clinical trial
- signaling pathway
- room temperature
- drug delivery
- randomized controlled trial
- endoplasmic reticulum stress
- study protocol
- oxidative stress
- stem cells
- cell therapy
- optical coherence tomography
- phase iii
- metabolic syndrome
- risk assessment
- cancer therapy
- ionic liquid
- phase ii
- resistance training
- human health