[Treatment of sleep disturbances associated with chronic non-specific low back pain: results of prospective randomized multicenter open-label clinical trial].

E R Barantsevich Yulia Karakulova N V BaranovaM V Morzhukhina

Published in: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (2022)

Naproxen sodium 440 mg/diphenhydramine 50 mg combination demonstrated improvement in sleep maintenance (WASO) vs. naproxen sodium 550 mg and higher efficiency in average daily pain reduction compared with the comparison groups. The treatment was well tolerated There were no serious or unexpected adverse events reported in the study.

Keyphrases

open label
clinical trial
double blind
phase ii
physical activity
phase iii
chronic pain
randomized controlled trial
placebo controlled
sleep quality
pain management
neuropathic pain
depressive symptoms
cross sectional