Increased spatial coupling of integrin and collagen IV in the immunoresistant clear cell renal cell carcinoma tumor microenvironment.
Alex C SoupirMitchell T HayesTaylor C PeakOscar E OspinaNicholas H ChakiryanAnders E BerglundPaul A StewartJonathan V NguyenCarlos Moran SeguraNatasha L FrancisPaola M Ramos EchevarriaJad ChahoudRoger LiKenneth Y TsaiJodi A BalasiYamila Caraballo PeresJasreman DhillonLindsey A MartinezWarren E GloriaNathan SchurmanSean KimMark GregoryJames J MuleBrooke L FridleyBrandon J ManleyPublished in: bioRxiv : the preprint server for biology (2023)
were more autocorrelated in IO-exposed stroma compared to IO-naïve tumors, with high expression amongst fibroblasts, tumor cells, and endothelium. Integrin represents a potential therapeutic target in IO treated ccRCC.