Effects of temporarily suspending low-dose methotrexate treatment for 2 weeks after SARS-CoV-2 vaccine booster on vaccine response in immunosuppressed adults with inflammatory conditions: protocol for a multicentre randomised controlled trial and nested mechanistic substudy (Vaccine Response On/Off Methotrexate (VROOM) study).

Abhishek AbhishekR J BoytonÁine McKnightLaura CoatesJames BluettVicki S BarberLucy CuretonAnne FrancisDuncan AppelbeLucy EldridgePatrick JulierNicholas PeckhamAna M ValdesInes RombachDaniel M AltmannJonathan Nguyen-Van-TamHywel C WilliamsJonathan Alistair Cook

Published in: BMJ open (2022)

ISRCTN11442263.

Keyphrases

low dose
sars cov
high dose
study protocol
randomized controlled trial
clinical trial
oxidative stress
respiratory syndrome coronavirus
cross sectional
coronavirus disease
double blind