Ablative radiotherapy improves survival but does not cure autochthonous mouse models of prostate and colorectal cancer.

Daniel R Schmidt Iva Monique T GramatikovAllison SheenChristopher L WilliamsMartina HurwitzLaura E DodgeEdward HolupkaW S KigerMilton R Cornwall-BradyWei HuangHoward H MakKathleen S CormierCharlene CondonKarl Dane Wittrup Ömer H YilmazMary Ann StevensonJulian D DownScott R FloydJatin RoperMatthew G Vander Heiden

Published in: Communications medicine (2023)

While SART is capable of fully ablating xenografts, it is unable to completely eradicate disease in GEMMs, arguing that resistance to potentially curative therapy can be modeled in GEMMs.

Keyphrases

mouse model
prostate cancer
early stage
locally advanced
rectal cancer
radiation therapy
benign prostatic hyperplasia
radiation induced
prognostic factors
stem cells
cell therapy