Transcriptome profile of highly osteoblastic/cementoblastic periodontal ligament cell clones.
Miki Taketomi SaitoLuciana Souto MofattoMayra Laino AlbieroMárcio Zafallon CasatiEnilson Antonio SallumFrancisco Humberto Nociti JuniorKarina Gonzalez Silvério RuizPublished in: Journal of applied oral science : revista FOB (2020)
This comprehensive transcriptomic assessment of human PDL progenitor cells revealed that expression of transcripts related to the biological process "anatomical structure development," Cadherin signaling, and Wnt signaling can identify PDL cells with a higher potential to commit to the O/C phenotype. A better understanding of these pathways and their function in O/C differentiation will help to improve protocols for periodontal regenerative therapies.
Keyphrases
- single cell
- rna seq
- cell therapy
- induced apoptosis
- endothelial cells
- stem cells
- poor prognosis
- cell cycle arrest
- mesenchymal stem cells
- gene expression
- induced pluripotent stem cells
- endoplasmic reticulum stress
- pluripotent stem cells
- oxidative stress
- vascular smooth muscle cells
- genome wide
- risk assessment
- bone marrow
- human health
- binding protein
- dna methylation
- cell migration
- pi k akt