Upregulation of Siglec-6 induces mitochondrial dysfunction by promoting GPR20 expression in early-onset preeclampsia.

Yuanhui JiaWenjing LuHan XieYifan ShengLuyao WangWenqi LvLijun LingJiaqi DongXinrui JiaShengyu WuWenqiang LiuHao Ying

Published in: Journal of translational medicine (2024)

This study indicates that the regulatory pathway Siglec-6/GPR20 has a crucial role in regulating trophoblast mitochondrial function, and we suggest that Siglec-6 and GPR20 could serve as potential markers and targets for the clinical diagnosis and therapy of EO-PE.

Keyphrases

early onset
late onset
poor prognosis
fatty acid
signaling pathway
cell proliferation
long non coding rna
transcription factor
stem cells
binding protein
bone marrow
pregnant women
pregnancy outcomes