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QL1701 (a proposed trastuzumab biosimilar) versus reference trastuzumab plus docetaxel as first-line therapy for HER2-positive metastatic breast cancer: a multicenter, randomized, double-blinded, parallel-controlled, phase III equivalence trial.

Q-Y ZhangR-G CaiG-H SongC-J LiB-H ZhangX-Y KangH-P LiB-H Xunull null
Published in: ESMO open (2024)
QL1701 demonstrated equivalent efficacy and similar safety to the reference trastuzumab when combined with docetaxel in the first-line treatment of patients with HER2-positive metastatic breast cancer, with similar PK and immunogenicity profiles.
Keyphrases
  • metastatic breast cancer
  • phase iii
  • double blind
  • open label
  • placebo controlled
  • clinical trial
  • phase ii
  • locally advanced
  • study protocol
  • randomized controlled trial
  • cross sectional
  • rectal cancer
  • tyrosine kinase