Mitochondrial fission protein 1 up-regulation ameliorates senescence-related endothelial dysfunction of human endothelial progenitor cells.

Hsueh-Hsiao WangYih-Jer WuYa-Ming TsengCheng-Huang SuChin-Ling HsiehHung-I Yeh

Published in: Angiogenesis (2019)

In human EPCs, down-regulation of Fis1 is involved in mitochondrial dysfunction and contributes to the impaired activity of EPCs during the senescence process. Enhanced expression of Fis1 in senescent EPCs restores the youthful phenotype.

Keyphrases

endothelial cells
induced pluripotent stem cells
oxidative stress
poor prognosis
pluripotent stem cells
binding protein
stress induced
small molecule
drug induced