Increased RUNX3 expression mediates tumor-promoting ability of human breast cancer-associated fibroblasts.

Yu KoyamaHiroya OkazakiYang ShiYoshihiro MezawaZixu WangMizuki SakimotoAkane IshizukaYasuhiko ItoTakumi KoyamaYataro DaigoAtsushi TakanoYohei MiyagiTomoyuki YokoseToshinari YamashitaKeisuke SugaharaOkio HinoLiying YangReo MaruyamaAkira KatakuraTakehiro YasukawaAkira Orimo

Published in: Cancer medicine (2023)

These results suggest that increased RUNX3 expression could contribute to the tumor-promoting ability of CAFs through mediating cancer cell growth and neoangiogenesis in human breast tumors.

Keyphrases

endothelial cells
poor prognosis
induced pluripotent stem cells
transcription factor
pluripotent stem cells
binding protein
extracellular matrix