CCR4 predicts the efficacy of abatacept in rheumatoid arthritis patients through the estimation of Th17 and Treg cell abundance.
Shigeru TanakaKeishi EtoriKoto HattoriJun TamuraKei IkedaTakahiro KageyamaKazuyuki MeguroTaro IwamotoArifumi IwataShunsuke FurutaAkira SutoKotaro SuzukiHiroshi NakajimaPublished in: Modern rheumatology (2023)
CCR4 is a Th17- and Treg-related gene, and the high CCR4 expression in peripheral blood samples may predict the efficacy of abatacept in RA.
Keyphrases
- rheumatoid arthritis patients
- disease activity
- rheumatoid arthritis
- peripheral blood
- dendritic cells
- regulatory t cells
- systemic lupus erythematosus
- poor prognosis
- ankylosing spondylitis
- single cell
- copy number
- genome wide
- stem cells
- immune response
- interstitial lung disease
- gene expression
- genome wide identification
- long non coding rna
- dna methylation
- microbial community