RIP-seq reveals LINE-1 ORF1p association with p-body enriched mRNAs.

Erica M BriggsWilson McKerrowPaolo MitaJef D BoekeSusan K LoganDavid Fenyo

Published in: Mobile DNA (2021)

Our results show a significant remodeling of LINE-1 loci expression in androgen independent cell lines when compared to parental androgen dependent cells. Additionally, we found that ORF1p bound a significant amount of non-LINE-1 mRNA, and that the enriched ORF1p bound mRNAs are also amplified in LINE-1 expressing TCGA prostate tumors, indicating the biological relevance of our findings to prostate cancer.

Keyphrases

prostate cancer
genome wide
induced apoptosis
poor prognosis
radical prostatectomy
single cell
gene expression
binding protein
cell cycle arrest
oxidative stress
cell proliferation
rna seq
genome wide association study