Recent Updates on the Therapeutic Prospects of Reversion-Inducing Cysteine-Rich Protein with Kazal Motifs (RECK) in Liver Injuries.
Giuseppina PalladiniLaura Giuseppina Di PasquaAnna Cleta CroceAndrea FerrignoGiuseppina PalladiniPublished in: International journal of molecular sciences (2023)
The reversion-inducing cysteine-rich protein with Kazal motifs (RECK), a membrane-anchored glycoprotein, negatively regulates various membrane proteins involved in the tissue governing extracellular matrix (ECM) remodeling such as metalloproteases (MMPs) and the sheddases ADAM10 and ADAM17. The significance of the present review is to summarize the current understanding of the pathophysiological role of RECK, a newly discovered signaling pathway associated with different liver injuries. Specifically, this review analyzes published data on the downregulation of RECK expression in hepatic ischemia/reperfusion (I/R) injury, liver-related cancers, including hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), as well as in the progression of nonalcoholic fatty liver disease (NAFLD) to non-alcoholic steatohepatitis (NASH). In addition, this review discusses the regulation of RECK by inducers, such as FXR agonists. The RECK protein has also been suggested as a potential diagnostic and prognostic marker for liver injury or as a biomarker with predictive value for drug treatment efficacy.
Keyphrases
- liver injury
- extracellular matrix
- drug induced
- signaling pathway
- binding protein
- protein protein
- amino acid
- poor prognosis
- epithelial mesenchymal transition
- fluorescent probe
- randomized controlled trial
- electronic health record
- emergency department
- young adults
- big data
- combination therapy
- long non coding rna
- risk assessment
- data analysis
- adverse drug
- single molecule