GMP-grade human neural progenitors delivered subretinally protect vision in rat model of retinal degeneration and survive in minipigs.

Bin LuPablo AvalosSoshana SvendsenChangqing ZhangLaura NocitoMelissa K JonesCosmo PieplowJoshua SaylorSean GhiamAmanda BlockMichael FernandezAlexander V LjubimovKent SmallDavid LiaoClive N SvendsenShaomei Wang

Published in: Journal of translational medicine (2023)

These extensive studies supported an approved IND and the translation of CNS10-NPC to an ongoing Phase 1/2a clinical trial (NCT04284293) for the treatment of retinitis pigmentosa.

Keyphrases

clinical trial
endothelial cells
optical coherence tomography
diabetic retinopathy
induced pluripotent stem cells
randomized controlled trial
combination therapy
pluripotent stem cells
double blind
pseudomonas aeruginosa
smoking cessation