The relationship between pain, analgesics and survival in patients with advanced cancer; a secondary data analysis of the international European palliative care Cancer symptom study.
Jason W BolandVictoria AllgarElaine G BolandMike I BennettStein KaasaMarianne Jensen HjermstadMiriam JohnsonPublished in: European journal of clinical pharmacology (2019)
Opioid-use and survival were associated; this relationship weakened in a small sensitivity-testing subgroup analysis adjusting for CRP. Thus, the observed relationship between survival and opioid-use may partly be due to tumour-related inflammation. Larger studies, measuring disease activity, are needed to confirm this finding to more accurately judge the benefits and risks of opioids in advanced progressive disease.
Keyphrases
- palliative care
- advanced cancer
- disease activity
- chronic pain
- rheumatoid arthritis
- systemic lupus erythematosus
- pain management
- free survival
- ankylosing spondylitis
- multiple sclerosis
- oxidative stress
- clinical trial
- squamous cell carcinoma
- neuropathic pain
- electronic health record
- randomized controlled trial
- big data
- spinal cord injury
- machine learning
- squamous cell
- spinal cord
- human health
- study protocol
- young adults