Multidrug chemotherapy, whole-brain radiation and cytarabine therapy for primary central nervous system lymphoma in elderly patients with dose modification based on geriatric assessment: study protocol for a phase II, multicentre, non-randomised study.
Fumiyuki YamasakiHirotaka FudabaKenichiro AsanoTakashi SasayamaManabu NatsumedaTaichi ShimabukuroKotaro TaguchiShinichiro KoizumiNoriyuki NakayamaKentaro FujiiIkuno NishibuchiKazuhiko SugiyamaKenji YoshidaUshio YonezawaMomii YasutomoYukari KawasakiKiyohide KakutaKosuke KatayamaKazuhiro TanakaHiroaki NagashimaYoshihiro TsukamotoMakoto IdeguchiTakafumi NishizakiKazuhiko KurozumiTomohiro HosoyaTomoyuki AkitaAtsushi KambePublished in: BMJ open (2023)
jRCTs061180093.
Keyphrases
- phase ii
- clinical trial
- open label
- double blind
- study protocol
- placebo controlled
- acute myeloid leukemia
- phase iii
- high dose
- resting state
- white matter
- drug resistant
- middle aged
- diffuse large b cell lymphoma
- locally advanced
- radiation induced
- squamous cell carcinoma
- functional connectivity
- radiation therapy
- cerebrospinal fluid
- randomized controlled trial
- cross sectional
- brain injury