LncRNA LINC00525 suppresses p21 expression via mRNA decay and triplex-mediated changes in chromatin structure in lung adenocarcinoma.

Panqi FangHao ChenZhifei MaChencheng HanWenda YinSiwei WangHongyu ZhuWenjia XiaJie WangLin XuTongyan LiuRong Yin

Published in: Cancer communications (London, England) (2021)

Our findings demonstrate that LINC00525 promotes the progression of LUAD by reducing the transcription and stability of p21 mRNA in concert with EZH2 and RBMS2, thus suggesting that LINC00525 may be a potential therapeutic target for clinical intervention in LUAD.

Keyphrases

long non coding rna
long noncoding rna
poor prognosis
binding protein
transcription factor
cell proliferation
randomized controlled trial
dna damage
gene expression
signaling pathway
genome wide
risk assessment
oxidative stress