Sociodemographic associations with uptake of novel therapies for acute myeloid leukemia.
Andrew HantelColin CernikHajime UnoThomas P WalshGregory Sampang CalipDaniel J DeAngeloChristopher S LathanGregory A AbelPublished in: Blood cancer journal (2023)
Inequitable uptake of novel therapies (NT) in non-cancer settings are known for patients with lower socioeconomic status (SES), People of Color (POC), and older adults. NT uptake equity in acute myeloid leukemia (AML) is not well known. We performed a retrospective cohort study (1/2014-8/2022) of the United States nationwide Flatiron Health TM electronic health record-derived, de-identified database. We estimated sociodemographic associations with AML NT receipt using incidence rate ratios (IRR). Odds ratios (OR) assessed differences in venetoclax (the most common NT) receipt at community sites and between site characteristics and NT adoption. Of 8081 patients (139 sites), 3102 (38%) received a NT. NT use increased annually (IRR 1.14, 95% confidence interval [1.07, 1.22]). NT receipt was similar between Non-Hispanic-Whites and POC (IRR 1.03, [0.91, 1.17]) and as age increased (IRR 1.02 [0.97, 1.07]). At community sites, Non-Hispanic-Whites were less likely to receive venetoclax (OR 0.77 [0.66, 0.91]); older age (OR 1.05 [1.04, 1.05]) and higher area-level SES were associated with venetoclax receipt (OR 1.23 [1.05, 1.43]). Early NT adopting sites had more prescribing physicians (OR 1.25 [1.13, 1.43]) and higher SES strata patients (OR 2.81 [1.08, 7.66]). Inequities in AML NT uptake were seen by SES; for venetoclax, differential uptake reflects its label indication for older adults and those with comorbidities.
Keyphrases
- acute myeloid leukemia
- electronic health record
- end stage renal disease
- healthcare
- primary care
- mental health
- ejection fraction
- newly diagnosed
- physical activity
- chronic kidney disease
- public health
- allogeneic hematopoietic stem cell transplantation
- squamous cell carcinoma
- chronic lymphocytic leukemia
- cross sectional
- adverse drug
- papillary thyroid
- acute lymphoblastic leukemia
- middle aged
- african american
- social media
- patient reported
- global health
- drug induced
- lymph node metastasis
- health promotion