Exploring the predictive potential of programmed death ligand 1 expression in healthy organs and lymph nodes as measured by 18 F-BMS986-192 PET: pooled analysis of data from four solid tumor types.
Iris H C MiedemaJohanna E E PouwAnne KwakmanGerben J C ZwezerijnenMarc C HuismanFlorentine E F TimmerRieneke van de VenTanja D de GruijlGeke A P HospersAdrianus J de LangenCatharina Willemien Menke-van der Houven van OordtPublished in: Journal for immunotherapy of cancer (2024)
PD-L1 PET uptake in the spleen is a potential negative predictor of response to ICIs. On-treatment with ICIs, PD-L1 uptake in benign TDLNs increases in non-responders, while it decreases in responders, potentially indicating a mechanism for resistance to ICIs in patients with oral cancer.