Acute expression of human APOBEC3B in mice results in RNA editing and lethality.
Alicia Alonso de la VegaNuri Alpay TemizRafail TasakisKalman SomogyiLorena SalgueiroEleni ZimmerMaria RamosAlberto Diaz-JimenezSara ChocarroMirian Fernández-VaqueroBojana StefanovskaEli ReuveniUri Ben-DavidAlbrecht StenzingerTanja PothMathias HeikenwälderNina PapavasiliouReuben S HarrisRocío SotilloPublished in: Genome biology (2023)
This work identifies, for the first time, a new deaminase-dependent function for APOBEC3B in RNA editing and presents a preclinical tool to help understand the emerging role of APOBEC3B as a driver of carcinogenesis.
Keyphrases
- crispr cas
- endothelial cells
- poor prognosis
- liver failure
- respiratory failure
- genome wide
- high fat diet induced
- pluripotent stem cells
- drug induced
- stem cells
- type diabetes
- dna methylation
- gene expression
- binding protein
- skeletal muscle
- hepatitis b virus
- extracorporeal membrane oxygenation
- acute respiratory distress syndrome