Tracking the brain in myotonic dystrophies: A 5-year longitudinal follow-up study.
Carla GliemMartina MinneropSandra RoeskeHanna GärtnerJan-Christoph Schoene-BakeSandra AdlerJuri-Alexander WittFelix HoffstaedterChristiane Schneider-GoldRegina C BetzChristoph HelmstaedterMarc TittgemeyerKatrin AmuntsThomas KlockgetherBernd WeberCornelia KornblumPublished in: PloS one (2019)
The lack of significant disease-related progression of gray and white matter involvement over a period of five years in our cohort of DM1 and DM2 patients suggests either a rather slowly progressive process or even a stable course of cerebral changes in middle-aged adult-onset patients. Being the first longitudinal neuroimaging trial in DM1 and DM2, this study provides useful additional information regarding the natural history of brain involvement.
Keyphrases
- white matter
- end stage renal disease
- ejection fraction
- chronic kidney disease
- multiple sclerosis
- middle aged
- prognostic factors
- peritoneal dialysis
- clinical trial
- randomized controlled trial
- study protocol
- cross sectional
- healthcare
- skeletal muscle
- resting state
- metabolic syndrome
- cerebral ischemia
- blood brain barrier
- brain injury
- weight loss
- insulin resistance